Sodium Iodide → 1-Iodooct-1-en-3-one

HRID 225077

反応式

HRID 225077 の反応式
Cl[CH:2]=[CH:3][C:4](=[O:10])[CH2:5][CH2:6][CH2:7][CH2:8][CH3:9].[I-:11].[Na+]>CC(C)=O>[I:11][CH:2]=[CH:3][C:4](=[O:10])[CH2:5][CH2:6][CH2:7][CH2:8][CH3:9]

参加物

4

反応物 2

HCID 5238Sodium IodideHCID 545149151-Chloro-1-octen-3-one

生成物 1

HCID 534008741-Iodooct-1-en-3-one収率 64.5%

試薬・触媒・溶媒 1

HCID 180Acetone溶媒

実験手順

A mixture of 25 g (0.16 moles) of 1-chloro-1-octen-3-one (Example 187) and 35 g (0.23 moles) of sodium iodide in 200 ml of reagent acetone is stirred at the reflux temperature for 18 hours. The cooled mixture is filtered and the mother liquor taken to dryness. The residual oil is dissolved in benzene and the solution is washed with 5% sodium thiosulfate solution, saturated sodium chloride solution, dried and taken to dryness. The residual oil is crystallized from hexane to give 26 g of a white solid, mp 35°-37° C.; λ max 1670, 950 cm-1.

後処理

  1. filtrationThe cooled mixture is filtered
  2. dissolutionThe residual oil is dissolved in benzene
  3. washthe solution is washed with 5% sodium thiosulfate solution, saturated sodium chloride solution
  4. customdried
  5. customThe residual oil is crystallized from hexane

出典と根拠

ORDレコード
ord-bb1498b96cab4cd29c5b14219fc0b575
出典データセット
uspto-grants-1980_11
特許番号
US04235797

関連ノート

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