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Triethylamine → 4-n-Hexyl-1-(5-hydroxypentyl)piperidine hydrochloride
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Triethylamine | HCID 8471 | — |
| 反応物 | Sodium Hydroxide | HCID 14798 | — |
| 反応物 | 5-Chloro-1-pentanol | HCID 78915 | — |
| 反応物 | 4-Hexylpiperidine | HCID 19069787 | — |
| 溶媒 | Toluene | HCID 1140 | — |
| 生成物 | 4-n-Hexyl-1-(5-hydroxypentyl)piperidine hydrochloride | HCID 23328916 | — |
反応手順
Seventeen (17) grams of 4-n-hexylpiperidine, 13 grams of 5-chloropentanol and 11 grams of triethylamine were dissolved in 100 ml. of toluene. The solution is heated in an autoclave for twelve hours at 120°-140° Centigrade. The solution is stirred with 200 ml. of 5-N NaOH. The organic phase is separated, dried, the solvent evaporated and the base distilled at 130°-135° Centigrade/0.01 mm Hg. The yield is 17.5 grams. The hydrochloride is obtained in the usual manner, according to Example 1, and melts at 142°-145° Centigrade.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04235875 |
| 出典データセット | uspto-grants-1980_11 |
| ORD ID | ord-bce880627c704ece9144a6a2c0ab5d16 |
| 出典メモ | uspto-grants-1980_11 |