反应详情

Seventeen (17) grams of 4-n-hexylpiperidine, 13 grams of 5-chloropentanol and 11 grams of triethylamine were dissolved in 100 ml. of toluene. The solution is heated in an autoclave for twelve hours at 120°-140° Centigrade. The solution is stirred with 200 ml. of 5-N NaOH. The organic phase is separated, dried, the solvent evaporated and the base distilled at 130°-135° Centigrade/0.01 mm Hg. The yield is 17.5 grams. The hydrochloride is obtained in the usual manner, according to Example 1, and melts at 142°-145° Centigrade.

1. temperatureThe solution is heated in an autoclave for twelve hours at 120°-140° Centigrade
2. customThe organic phase is separated
3. customdried
4. customthe solvent evaporated
5. distillationthe base distilled at 130°-135° Centigrade/0.01 mm Hg