Anthranilic Acid → 2-Cyclohexylideneamino-benzoic acid
反応式
[C:1]([OH:10])(=[O:9])[C:2]1[C:3](=[CH:5][CH:6]=[CH:7][CH:8]=1)[NH2:4].[C:11]1(=O)[CH2:16][CH2:15][CH2:14][CH2:13][CH2:12]1>>[C:11]1(=[N:4][C:3]2[CH:5]=[CH:6][CH:7]=[CH:8][C:2]=2[C:1]([OH:10])=[O:9])[CH2:16][CH2:15][CH2:14][CH2:13][CH2:12]1参加物
3
実験手順
Anthranilic acid (10 g, 73 mmol) and cyclohexanone (9.8 mL, 95 mmol) were dissolved in xylenes (110 mL) in a flask equipped with a Dean-Stark apparatus and heated to reflux over 18 hours. The reaction mixture was cooled to room temperature and the resulting precipitate collected by filtration. The filter cake was washed with hexanes and dried in vacuo to give the desired imine (11 g, 69% yield) as a beige solid.
後処理
- customequipped with a Dean-Stark apparatus
- temperatureheated
- temperatureto reflux over 18 hours
- filtrationthe resulting precipitate collected by filtration
- washThe filter cake was washed with hexanes
- customdried in vacuo
出典と根拠
- ORDレコード
- ord-d553c0b93bf74137ae24610895f8dc5b
- 出典データセット
- uspto-grants-2008_01
- 特許番号
- US07319103B2
反応ノート
読み込み中…