Hydrazine hydrate (1:1) → 4-(3-Dimethylaminopyrrolidin-1-yl)benzohydrazide

HRID 2251292ノート

反応式

HRID 2251292 の反応式
[CH3:1][N:2]([CH3:19])[CH:3]1[CH2:7][CH2:6][N:5]([C:8]2[CH:18]=[CH:17][C:11]([C:12](OCC)=[O:13])=[CH:10][CH:9]=2)[CH2:4]1.O.[NH2:21][NH2:22]>C(O)C>[CH3:1][N:2]([CH3:19])[CH:3]1[CH2:7][CH2:6][N:5]([C:8]2[CH:18]=[CH:17][C:11]([C:12]([NH:21][NH2:22])=[O:13])=[CH:10][CH:9]=2)[CH2:4]1

参加物

4

反応物 2

HCID 24654Hydrazine hydrate (1:1)HCID 69209289Ethyl 4-(3-dimethylaminopyrrolidin-1-yl)benzoate

生成物 1

HCID 692131084-(3-Dimethylaminopyrrolidin-1-yl)benzohydrazide

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

反応条件

温度
5 °C

実験手順

A mixture of ethyl 4-(3-dimethylaminopyrrolidin-1-yl)benzoate (2.0 g), hydrazine hydrate (3.8 g) and ethanol (7 ml) was boiled under reflux for 15 hours. After cooling to 5° C., the resulting precipitate was filtered off with suction. The product with the molecular weight of 248.33 (C13H20N4O) was obtained in this way; MS (ESI): 249 (M+H+).

後処理

  1. temperatureunder reflux for 15 hours
  2. filtrationthe resulting precipitate was filtered off with suction
  3. customThe product with the molecular weight of 248.33 (C13H20N4O) was obtained in this way

出典と根拠

ORDレコード
ord-13da222b8a284726b4e6314b1c964c5d
出典データセット
uspto-grants-2008_01
特許番号
US07319108B2

反応ノート

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