Diisopropylethylamine → HCID 59643341、化合物
反応式
[F:1][C:2]([F:21])([F:20])[C:3]1[CH:19]=[CH:18][C:6]([CH2:7][NH:8][CH2:9][CH2:10][C:11]2[CH:16]=[CH:15][C:14]([OH:17])=[CH:13][CH:12]=2)=[CH:5][CH:4]=1.Cl[C:23]1[N:28]=[CH:27][C:26]([CH2:29][CH3:30])=[CH:25][N:24]=1.CCN(C(C)C)C(C)C>C1(C)C=CC=CC=1>[CH2:29]([C:26]1[CH:25]=[N:24][C:23]([N:8]([CH2:7][C:6]2[CH:5]=[CH:4][C:3]([C:2]([F:20])([F:21])[F:1])=[CH:19][CH:18]=2)[CH2:9][CH2:10][C:11]2[CH:16]=[CH:15][C:14]([OH:17])=[CH:13][CH:12]=2)=[N:28][CH:27]=1)[CH3:30]参加物
5
実験手順
Condensation of 4-(2-{[4-(trifluoromethyl)benzyl]amino}ethyl)phenol (1.20 g; 4.06 mmol) with 2-chloro-5-ethyl-pyrimidine (0.52 ml; 4.27 mmol) as per general procedure E (conditions: 1.1 eq. DIEA, toluene, 210C, 16 hr) provided the title compound (1.40 g; 85% yield).