Hydrochloric Acid → 5-Isopropylpyrimidin-2(1H)-one
反応式
C(O[CH:4]=[C:5]([CH:8]([CH3:10])[CH3:9])[CH:6]=O)C.[NH2:11][C:12]([NH2:14])=[O:13].Cl.[OH-].[Na+]>C(O)C>[CH:8]([C:5]1[CH:6]=[N:11][C:12](=[O:13])[NH:14][CH:4]=1)([CH3:9])[CH3:10]参加物
6
実験手順
A mixture of 3-ethoxy-2-isopropylprop-2-enal (ref. Menicagli, R. et al. Tetrahedron 1987, 43, 171–177) (250 mg, 1.76 mmol) and urea (250 mg, 4.16 mmol) in ethanol (2.5 ml) was treated with concentrated HCl (0.5 ml) and heated to reflux for 1 hour. Upon cooling, the reaction mixture was neutralized with 1N NaOH (0.6 ml) and extracted with chloroform. The organic layer was dried over MgSO4 and concentrated to provide 5-isopropylpyrimidin-2(1H)-one as an off-white solid (0.20 g; 82% yield).
後処理
- temperatureheated
- temperatureto reflux for 1 hour
- temperatureUpon cooling
- extractionextracted with chloroform
- dry with materialThe organic layer was dried over MgSO4
- concentrationconcentrated
出典と根拠
- ORDレコード
- ord-d8b2ddbdfac140caa5cebb30e69b1306
- 出典データセット
- uspto-grants-2008_01
- 特許番号
- US07319104B2
反応ノート
読み込み中…