Potassium Carbonate → (R)-N-[1-(4-Pyrrolidinophenethyl)pyrrolidin-3-yl]-2-(2-bromobenzyloxy)aniline

HRID 2251914ノート

反応式

HRID 2251914 の反応式
CS(O[C@H:6]1[CH2:10][CH2:9][N:8]([CH2:11][CH2:12][C:13]2[CH:18]=[CH:17][C:16]([N:19]3[CH2:23][CH2:22][CH2:21][CH2:20]3)=[CH:15][CH:14]=2)[CH2:7]1)(=O)=O.[Br:24][C:25]1[CH:39]=[CH:38][CH:37]=[CH:36][C:26]=1[CH2:27][O:28][C:29]1[CH:35]=[CH:34][CH:33]=[CH:32][C:30]=1[NH2:31].C(=O)([O-])[O-].[K+].[K+]>C(#N)C>[N:19]1([C:16]2[CH:17]=[CH:18][C:13]([CH2:12][CH2:11][N:8]3[CH2:9][CH2:10][C@@H:6]([NH:31][C:30]4[CH:32]=[CH:33][CH:34]=[CH:35][C:29]=4[O:28][CH2:27][C:26]4[CH:36]=[CH:37][CH:38]=[CH:39][C:25]=4[Br:24])[CH2:7]3)=[CH:14][CH:15]=2)[CH2:23][CH2:22][CH2:21][CH2:20]1

参加物

5

反応物 3

HCID 11430Potassium CarbonateHCID 112081902-(o-Bromobenzyloxy) anilineHCID 59643988(S)-3-methanesulfonyloxy-1-(4-pyrrolidinophenethyl)pyrrolidine

生成物 1

HCID 69200293(R)-N-[1-(4-Pyrrolidinophenethyl)pyrrolidin-3-yl]-2-(2-bromobenzyloxy)aniline

試薬・触媒・溶媒 1

HCID 6342Acetonitrile溶媒2 回

実験手順

(S)-3-Methanesulfonyloxy-1-(4-pyrrolidinophenethyl)pyrrolidine (0.30 g, 0.89 mmol) was added to 2-(2-bromobenzyloxy)aniline (1.15 g, 4.13 mmol) in argon stream. The obtained mixture was dissolved in acetonitrile (50 ml). Potassium carbonate (1.62 g, 11.7 mmol) was added to the obtained solution, and they were refluxed for 85 hours. Acetonitrile (15 ml) was added to the reaction mixture, and they were refluxed for additional 48 hours. The reaction mixture was filtered through Celite to obtain the filtrate. The solvent was evaporated under reduced pressure to obtain the title compound in the form of a brown oily mixture (1.40 g).

後処理

  1. temperaturewere refluxed for 85 hours
  2. temperaturewere refluxed for additional 48 hours
  3. filtrationThe reaction mixture was filtered through Celite
  4. customto obtain the filtrate
  5. customThe solvent was evaporated under reduced pressure

出典と根拠

ORDレコード
ord-c502d0469d1446b08c33f2fa20d0e565
出典データセット
uspto-grants-2008_01
特許番号
US07320973B2

反応ノート

読み込み中…