Hydrochloric Acid → HCID 59645229、化合物

反応式

[OH-].[Na+].[OH:3][C:4]1[C:5]([C:20]([O:22]C)=[O:21])=[N:6][C:7]([N:14]([CH3:19])[S:15]([CH3:18])(=[O:17])=[O:16])=[C:8]2[C:13]=1[N:12]=[CH:11][CH:10]=[CH:9]2.Cl>C1COCC1.CO>[OH:3][C:4]1[C:5]([C:20]([OH:22])=[O:21])=[N:6][C:7]([N:14]([CH3:19])[S:15]([CH3:18])(=[O:17])=[O:16])=[C:8]2[C:13]=1[N:12]=[CH:11][CH:10]=[CH:9]2

参加物

反応条件

温度: 50 °C

実験手順

Sodium hydroxide (2.31 mL, 2.31 mmol, 1N solution) was added to a suspension of methyl 8-hydroxy-5-[methyl(methylsulfonyl)amino]-1,6-naphthyridine-7-carboxylate (240 mg, 0.77 mmol) in a 1:1 solution of THF/methanol (5 mL) and the resulting mixture was heated overnight at 50° C. In the morning, the homogeneous solution was acidified to a pH=4 using 1N HCl solution. The reaction was cooled and the solids that had precipitated out of solution were collected by vacuum filtration to give the desired product as an off-white solid.