Sodium Hydroxide → Sodium 5-(1,1-dioxido-1,2-thiazinan-2-yl)-7-[({4-fluoro-2-[(isopropylamino)carbonyl]benzyl}amino)carbonyl]-1,6-naphthyridin-8-olate

HRID 2252814ノート

反応式

HRID 2252814 の反応式
[O:1]=[S:2]1(=[O:36])[CH2:7][CH2:6][CH2:5][CH2:4][N:3]1[C:8]1[N:17]=[C:16]([C:18]([NH:20][CH2:21][C:22]2[CH:27]=[CH:26][C:25]([F:28])=[CH:24][C:23]=2[C:29]([NH:31][CH:32]([CH3:34])[CH3:33])=[O:30])=[O:19])[C:15]([OH:35])=[C:14]2[C:9]=1[CH:10]=[CH:11][CH:12]=[N:13]2.[OH-].[Na+:38]>CC(C)=O>[O:36]=[S:2]1(=[O:1])[CH2:7][CH2:6][CH2:5][CH2:4][N:3]1[C:8]1[N:17]=[C:16]([C:18]([NH:20][CH2:21][C:22]2[CH:27]=[CH:26][C:25]([F:28])=[CH:24][C:23]=2[C:29]([NH:31][CH:32]([CH3:34])[CH3:33])=[O:30])=[O:19])[C:15]([O-:35])=[C:14]2[C:9]=1[CH:10]=[CH:11][CH:12]=[N:13]2.[Na+:38]

参加物

4

反応物 2

HCID 14798Sodium HydroxideHCID 30134005-(1,1-dioxothiazinan-2-yl)-N-[[4-fluoro-2-(isopropylcarbamoyl)phenyl]methyl]-8-hydroxy-1,6-naphthyridine-7-carboxamide

生成物 1

HCID 69178932Sodium 5-(1,1-dioxido-1,2-thiazinan-2-yl)-7-[({4-fluoro-2-[(isopropylamino)carbonyl]benzyl}amino)carbonyl]-1,6-naphthyridin-8-olate

試薬・触媒・溶媒 1

HCID 180Acetone溶媒

実験手順

5-(1,1-Dioxido-1,2-thiazinan-2-yl)-N-{4-fluoro-2-[(isopropylamino)carbonyl]benzyl}-8-hydroxy-1,6-naphthyridine-7-carboxamide (203 mg, 0.39 mmol) was suspended in acetone (2 mL) and sodium hydroxide (0.39 mL, 0.39 mmol, 1N aqueous solution) was added. The flask was gently warmed to make the solution homogeneous and the solution was then filtered through a glass fiber filter to remove any dust. The solution was stirred at room temperature until solids crashed out of solution. The solids were collected by vacuum filtration to give the title compound as a yellow solid.

後処理

  1. temperatureThe flask was gently warmed
  2. filtrationthe solution was then filtered through a glass fiber
  3. filtrationfilter
  4. customto remove any dust
  5. filtrationThe solids were collected by vacuum filtration

出典と根拠

ORDレコード
ord-2bc9496928ab47eaac43eadf78235904
出典データセット
uspto-grants-2008_01
特許番号
US07323460B2

反応ノート

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