反応式
[P].[F:2][C:3]([F:20])([F:19])[C:4]1[CH:9]=[CH:8][CH:7]=[C:6]([C:10]2[N:15]3[N:16]=[CH:17][CH:18]=[C:14]3[N:13]=[CH:12][CH:11]=2)[CH:5]=1.[OH-].[Na+].CN(C)[CH:25]=[O:26]>>[F:20][C:3]([F:19])([F:2])[C:4]1[CH:9]=[CH:8][CH:7]=[C:6]([C:10]2[N:15]3[N:16]=[CH:17][C:18]([CH:25]=[O:26])=[C:14]3[N:13]=[CH:12][CH:11]=2)[CH:5]=1参加物
5
実験手順
Seventy-five milliliters of dried dimethylformamide is cooled in an ice bath and 25 ml. of phosphorus osychloride is added dropwise with swirling. To this ice cold mixture is added 19.5 g. of 7-(α,α,α-trifluoro-m-tolyl)pyrazolo[1,5-a]pyrimidine in one portion and the reaction mixture is then heated on a steam bath for 1.5 hours. The mixture is poured onto ice and made basic (pH 10) with 10 N NaOH. The precipitated solid is removed by filtration and recrystallized from methylene chloride-hexane to give the product, m.p. 196°-198° C.
後処理
- additionThe mixture is poured onto ice
- customThe precipitated solid is removed by filtration
- customrecrystallized from methylene chloride-hexane
- customto give the product, m.p. 196°-198° C.
出典と根拠
- ORDレコード
- ord-efe35094456244b4878fa9c8652b6426
- 出典データセット
- uspto-grants-1980_11
- 特許番号
- US04236005
関連ノート
読み込み中…