Acetic Acid → 4-(4-(4-Chlorophenyl)-1-hydroxybutyl)phenol

HRID 2253756ノート

反応式

HRID 2253756 の反応式
[F-].C([N+](CCCC)(CCCC)CCCC)CCC.CC([Si](C1C=CC=CC=1)(C1C=CC=CC=1)[O:24][C:25]1[CH:30]=[CH:29][C:28]([CH:31]([OH:42])[CH2:32][CH2:33][CH2:34][C:35]2[CH:40]=[CH:39][C:38]([Cl:41])=[CH:37][CH:36]=2)=[CH:27][CH:26]=1)(C)C.CC(O)=O>C1COCC1>[Cl:41][C:38]1[CH:39]=[CH:40][C:35]([CH2:34][CH2:33][CH2:32][CH:31]([C:28]2[CH:27]=[CH:26][C:25]([OH:24])=[CH:30][CH:29]=2)[OH:42])=[CH:36][CH:37]=1

参加物

5

反応物 3

HCID 176Acetic AcidHCID 2724141Tetrabutylammonium FluorideHCID 538578064-(4-Chlorophenyl)-1-(4-t-butyldiphenylsiloxy phenyl)butanol

生成物 1

HCID 197458724-(4-(4-Chlorophenyl)-1-hydroxybutyl)phenol

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

反応条件

温度
0 °C

実験手順

At 0° C., 1M tetrabutylammonium fluoride (100 mL) was added to a solution of the silyl ether of Step 2 (34 g) and AcOH (15 mL) in THF (200 mL) and the reaction mixture was stirred at 0° C. 2.5 hours. 25% aqueous NH4OAc was then added and the product was extracted with EtOAc, dried over MgSO4 and purified by a swish in EtOAc:hexane 1:2. The title compound so obtained was used as such for the next step.

後処理

  1. custom2.5 hours
  2. extractionthe product was extracted with EtOAc
  3. dry with materialdried over MgSO4
  4. custompurified by a swish in EtOAc:hexane 1:2

出典と根拠

ORDレコード
ord-fd7a1b5326a241b2b75c562504967ad6
出典データセット
uspto-grants-1993_08
特許番号
US05232916

反応ノート

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