Methyl iodide → HCID 14078470、化合物

HRID 2254201ノート

反応式

HRID 2254201 の反応式
[OH:1][C:2]1[C:7]([CH2:8][CH:9]=[C:10]([CH3:12])[CH3:11])=[C:6]([OH:13])[CH:5]=[CH:4][C:3]=1[C:14](=[O:16])[CH3:15].[C:17](=O)([O-])[O-].[K+].[K+].CI>CC(C)=O>[OH:1][C:2]1[C:7]([CH2:8][CH:9]=[C:10]([CH3:11])[CH3:12])=[C:6]([O:13][CH3:17])[CH:5]=[CH:4][C:3]=1[C:14](=[O:16])[CH3:15]

参加物

5

反応物 3

HCID 6328Methyl iodideHCID 11430Potassium CarbonateHCID 109329712',4'-dihydroxy-3'-prenylacetophenone

生成物 1

HCID 14078470HCID 14078470、化合物収率 99.1%

試薬・触媒・溶媒 1

HCID 180Acetone溶媒

実験手順

Then, 19.00 g of 2',4'-dihydroxy-3'-(3-methyl-2-butenyl)acetophenone was dissolved in 160 ml of acetone, and 14.29 g of anhydrous potassium carbonate and 6.2 ml of methyl iodide were added to the solution and the mixture was stirred at room temperature in a nitrogen current overnight. After the reaction, the solvent was removed by distillation and the obtained residue was extracted with ether, the extract was washed with water, dried with anhydrous sodium sulfate, and filtered. The solvent was removed from the filtrate by distillation to obtain 20.02 g (yield=99.1%) of 2'-hydroxy-4'-methoxy-3'-(3-methyl-2-butenyl)acetophenone in the form of a colorless oil.

後処理

  1. customAfter the reaction
  2. customthe solvent was removed by distillation
  3. extractionthe obtained residue was extracted with ether
  4. washthe extract was washed with water
  5. dry with materialdried with anhydrous sodium sulfate
  6. filtrationfiltered
  7. customThe solvent was removed from the filtrate by distillation

出典と根拠

ORDレコード
ord-f23f6e6bd59941b8974866ecc2679c6b
出典データセット
uspto-grants-1993_08
特許番号
US05234951

反応ノート

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