Thiophene → 2-(7-Methoxycarbonyl-1-oxoheptyl)thiophene

HRID 2254324

反応式

HRID 2254324 の反応式
[CH3:1][O:2][C:3](=[O:13])[CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][C:10]([OH:12])=O.ClCC(OC(=O)CCl)=O.[S:23]1[CH:27]=[CH:26][CH:25]=[CH:24]1>ClC(Cl)C>[CH3:1][O:2][C:3]([CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][C:10]([C:24]1[S:23][CH:27]=[CH:26][CH:25]=1)=[O:12])=[O:13]

参加物

5

反応物 3

HCID 8030ThiopheneHCID 10946Chloroacetic anhydrideHCID 5541918-Methoxy-8-oxooctanoic acid

生成物 1

HCID 197452382-(7-Methoxycarbonyl-1-oxoheptyl)thiophene収率 91%

試薬・触媒・溶媒 1

HCID 63651,1-Dichloroethane溶媒

反応条件

温度
60 °C

実験手順

In 50 ml of dichloroethane were dissolved 9.41 g (0.05 mole) of suberic acid monomethyl ester and 9.83 g (0.0575 mole) of monochloroacetic anhydride. To the resulting solution were added 5.47 g (0.065 mole) of thiophene and 0.71 g of boron trifluoride-diethyl ether complex and the resulting mixture was then stirred at 60° C. for 5 hours. After completion of the reaction, the reaction solution was cooled and washed successively with water, 5% aqueous sodium carbonate solution and water. The organic layer was dried over anhydrous magnesium sulfate and then concentrated under reduced pressure to obtain 11.5 g of 2-(7-methoxycarbonyl-1-oxoheptyl)thiophene.

後処理

  1. customAfter completion of the reaction
  2. temperaturethe reaction solution was cooled
  3. washwashed successively with water, 5% aqueous sodium carbonate solution and water
  4. dry with materialThe organic layer was dried over anhydrous magnesium sulfate
  5. concentrationconcentrated under reduced pressure

出典と根拠

ORDレコード
ord-3c9d73751140432cab76c4d321254801
出典データセット
uspto-grants-1993_08
特許番号
US05235068

関連ノート

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