Water → HCID 19744765、化合物

HRID 2254427ノート

反応式

HRID 2254427 の反応式
[C:1]1([C:7]#[C:8][C:9]2[CH:10]=[C:11]([CH:14]=[CH:15][CH:16]=2)[CH2:12]O)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.P(Br)(Br)[Br:18].O>C(Cl)(Cl)Cl>[C:1]1([C:7]#[C:8][C:9]2[CH:10]=[C:11]([CH:14]=[CH:15][CH:16]=2)[CH2:12][Br:18])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

参加物

5

反応物 3

HCID 962WaterHCID 24614Phosphorus tribromideHCID 54519030123926-88-5

生成物 1

HCID 19744765HCID 19744765、化合物収率 99%

試薬・触媒・溶媒 1

HCID 6212Chloroform溶媒2 回

実験手順

The resulting acetylene compound (116 mg) was dissolved in 1 ml of chloroform, and 0.1 ml of phosphorus tribromide was added. The mixture was stirred at room temperature for 1 hour. Water and chloroform were added to the reaction mixture. The organic layer was separated, washed with a saturated aqueous solution of sodium hydrogen carbonate and water, and then dried over anhydrous sodium sulfate. The desiccant was removed by filtration, and the filtrate was evaporated under reduced pressure to give 150 mg (yield 99%) of the captioned compound as a colorless oil.

後処理

  1. customThe organic layer was separated
  2. washwashed with a saturated aqueous solution of sodium hydrogen carbonate and water
  3. dry with materialdried over anhydrous sodium sulfate
  4. customThe desiccant was removed by filtration
  5. customthe filtrate was evaporated under reduced pressure

出典と根拠

ORDレコード
ord-35538b78fcb54098ad39eec989362db4
出典データセット
uspto-grants-1993_08
特許番号
US05234946

反応ノート

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