5-(p-Cyanophenyl)imidazo[1,5-a]pyridine hydrochloride → Fadrozole

HRID 22547

反応式

HRID 22547 の反応式
Cl.[C:2]([C:4]1[CH:9]=[CH:8][C:7]([C:10]2[N:15]3[CH:16]=[N:17][CH:18]=[C:14]3[CH:13]=[CH:12][CH:11]=2)=[CH:6][CH:5]=1)#[N:3]>CO.[Pd]>[C:2]([C:4]1[CH:5]=[CH:6][C:7]([CH:10]2[N:15]3[CH:16]=[N:17][CH:18]=[C:14]3[CH2:13][CH2:12][CH2:11]2)=[CH:8][CH:9]=1)#[N:3]

参加物

4

反応物 1

HCID 199304145-(p-Cyanophenyl)imidazo[1,5-a]pyridine hydrochloride

生成物 1

HCID 59693Fadrozole

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 887Methanol溶媒

実験手順

A solution of 54 mg of 5-(p-cyanophenyl)imidazo[1,5-a]pyridine hydrochloride in 5.0 ml methanol is hydrogenated at room temperature and atmospheric pressure for 30 min with 0.1 g of 10% palladium on charcoal. The catalyst is filtered and 0.21 ml of 1N sodium hydroxide is added. The filtrate is evaporated, taken up in 10 ml of methylene chloride and filtered through Celite®. Evaporation yields an oil which is chromatographed on silica gel with ethyl acetate to yield the title compound, m.p. 117°-118°.

後処理

  1. customis hydrogenated at room temperature
  2. filtrationThe catalyst is filtered
  3. addition0.21 ml of 1N sodium hydroxide is added
  4. customThe filtrate is evaporated
  5. filtrationfiltered through Celite®
  6. customEvaporation
  7. customyields an oil which
  8. customis chromatographed on silica gel with ethyl acetate

出典と根拠

ORDレコード
ord-8a23494cdaa649afb524d0557bf17ef6
出典データセット
uspto-grants-1995_06
特許番号
US05428160

関連ノート

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