Acetic Anhydride → 3-Cyano-2-fluoro-6-methoxyphenyl acetate

HRID 2254765ノート

反応式

HRID 2254765 の反応式
[F:1][C:2]1[C:9]([OH:10])=[C:8]([O:11][CH3:12])[CH:7]=[CH:6][C:3]=1[C:4]#[N:5].[C:13](OC(=O)C)(=[O:15])[CH3:14]>N1C=CC=CC=1>[C:13]([O:10][C:9]1[C:8]([O:11][CH3:12])=[CH:7][CH:6]=[C:3]([C:4]#[N:5])[C:2]=1[F:1])(=[O:15])[CH3:14]

参加物

4

反応物 2

HCID 7918Acetic AnhydrideHCID 214591072-Fluoro-3-hydroxy-4-methoxybenzonitrile

生成物 1

HCID 539089783-Cyano-2-fluoro-6-methoxyphenyl acetate

試薬・触媒・溶媒 1

HCID 1049Pyridine溶媒

実験手順

0.9 g of 2-fluoro-3-hydroxy-p-anisonitrile are dissolved in 10 ml of acetic anhydride and 0.5 ml of pyridine, whereupon the mixture is stirred at 120° for 2 hours. The reaction mixture is subsequently evaporated and the residue is partitioned between ice-water and methylene chloride. The organic phase is dried over sodium sulfate and evaporated, and the residue is recyrstallized from methylene chloride/hexane. There is obtained 3-cyano-2-fluoro-6-methoxyphenyl acetate of m.p. 90°-91°.

後処理

  1. customThe reaction mixture is subsequently evaporated
  2. customthe residue is partitioned between ice-water and methylene chloride
  3. dry with materialThe organic phase is dried over sodium sulfate
  4. customevaporated

出典と根拠

ORDレコード
ord-a993be5b853e4ba48e6b492c8d42836a
出典データセット
uspto-grants-1993_08
特許番号
US05236952

反応ノート

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