Hydrochloric Acid → 4-Chloro-N-(2-hydroxyethyl)benzamide
反応式
[Cl:1][C:2]1[CH:10]=[CH:9][C:5]([C:6](Cl)=[O:7])=[CH:4][CH:3]=1.[CH2:11]([CH2:13][NH2:14])[OH:12].C(N(CC)CC)C.Cl>C(Cl)Cl>[OH:12][CH2:11][CH2:13][NH:14][C:6](=[O:7])[C:5]1[CH:9]=[CH:10][C:2]([Cl:1])=[CH:3][CH:4]=1参加物
6
実験手順
2.6 ml (0.02 mol) of 4-chlorobenzoyl chloride are added dropwise at 0° to a solution of 1.2 ml (0.02 mol) of ethanolamine and 3 ml (about 0.02 mol) of triethylamine in 30 ml of methylene chloride. The mixture is then poured into dilute hydrochloric acid and extracted twice with methylene chloride. The methylene chloride extracts are dried over magnesium sulfate and concentrated. After purification on silica gel using chloroform and chloroform/methanol 9:1) as the eluting agent, there are obtained 3.1 g of N-(2-hydroxyethyl)-4-chlorobenzamide.
後処理
- extractionextracted twice with methylene chloride
- dry with materialThe methylene chloride extracts are dried over magnesium sulfate
- concentrationconcentrated
- customAfter purification on silica gel
出典と根拠
- ORDレコード
- ord-7dbe95ea779e4c689c1d27dc938a8b5b
- 出典データセット
- uspto-grants-1993_08
- 特許番号
- US05238962
反応ノート
読み込み中…