Sodium Hydroxide → 2-(2,4-Dichlorophenyl)-3-(1-methylpiperidin-3-yl)propionitrile
反応式
[Cl:1][C:2]1[CH:10]=[C:9]([Cl:11])[CH:8]=[CH:7][C:3]=1[CH2:4][C:5]#[N:6].Cl.Cl[CH2:14][CH:15]1[CH2:20][CH2:19][CH2:18][N:17]([CH3:21])[CH2:16]1.[OH-].[Na+]>CS(C)=O>[Cl:1][C:2]1[CH:10]=[C:9]([Cl:11])[CH:8]=[CH:7][C:3]=1[CH:4]([CH2:14][CH:15]1[CH2:20][CH2:19][CH2:18][N:17]([CH3:21])[CH2:16]1)[C:5]#[N:6]参加物
5
実験手順
This intermediate (7.6 g.) was prepared using the procedure described in Example 14a except using 10 g. (0.054 mole) of 2,4-dichlorobenzyl cyanide, 10 g. (0.054 mole) of 3-chloromethyl-1-methylpiperidine hydrochloride, 11 g. (0.135 mole) of aqueous 50% sodium hydroxide, and 100 ml. of DMSO to yield an oil boiling 160°-165° C. at 5 mm of Hg.
後処理
- customThis intermediate (7.6 g.) was prepared
- customboiling 160°-165° C. at 5 mm of Hg
出典と根拠
- ORDレコード
- ord-507d7a63dffb4cb1a0879d3fb6b4dc27
- 出典データセット
- uspto-grants-1993_08
- 特許番号
- US05240925
反応ノート
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