Butylamine → N-n-butyl-3-methyl-5-isothiazolecarboxylic acid amide

HRID 2255487ノート

反応式

HRID 2255487 の反応式
[CH3:1][C:2]1[CH:6]=[C:5]([C:7]([OH:9])=O)[S:4][N:3]=1.C(N(CC)CC)C.[CH2:17]([NH2:21])[CH2:18][CH2:19][CH3:20]>C(OCC)(=O)C>[CH2:17]([NH:21][C:7]([C:5]1[S:4][N:3]=[C:2]([CH3:1])[CH:6]=1)=[O:9])[CH2:18][CH2:19][CH3:20]

参加物

5

反応物 3

HCID 8007ButylamineHCID 8471TriethylamineHCID 2740923-Methyl-1,2-thiazole-5-carboxylic acid

生成物 1

HCID 54219434N-n-butyl-3-methyl-5-isothiazolecarboxylic acid amide

試薬・触媒・溶媒 1

HCID 8857Ethyl Acetate溶媒

実験手順

3-Methyl-5-isothiazolecarboxylic acid (2.3 g) was dissolved in 40 ml of ethyl acetate. After 2 g of triethylamine were added, the resultant mixture was cooled over an ice-water bath and, at 5°-10° C., 1.5 g of n-butylamine were gradually added dropwise. After completion of the dropwise addition, stirring was continued for 30 minutes. The reaction mixture was washed successively with an aqueous solution of sodium hydrogencarbonate and then with water. After dried over sodium sulfate, the solvent was distilled off so that 2.60 g of N-n-butyl-3-methyl-5-isothiazolecarboxylic acid amide were obtained as an oil.

後処理

  1. additionAfter completion of the dropwise addition
  2. washThe reaction mixture was washed successively with an aqueous solution of sodium hydrogencarbonate
  3. dry with materialAfter dried over sodium sulfate
  4. distillationthe solvent was distilled off so that 2.60 g of N-n-butyl-3-methyl-5-isothiazolecarboxylic acid amide
  5. customwere obtained as an oil

出典と根拠

ORDレコード
ord-d47183f2e5b3454a9a311f81fb228e31
出典データセット
uspto-grants-1993_08
特許番号
US05240951

反応ノート

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