Sodium borohydride → (2-Fluoro-6-hydroxymethyl-4-trifluoromethyl-phenyl)-methanol

反応式

[F:1][C:2]1[CH:10]=[C:9]([C:11]([F:14])([F:13])[F:12])[CH:8]=[C:7]2[C:3]=1[CH2:4][O:5][C:6]2=[O:15].[BH4-].[Na+]>>[F:1][C:2]1[CH:10]=[C:9]([C:11]([F:14])([F:13])[F:12])[CH:8]=[C:7]([CH2:6][OH:15])[C:3]=1[CH2:4][OH:5]

参加物

反応物 2

HCID 4311764Sodium borohydride

HCID 577532554-Fluoro-6-trifluoromethyl-3H-isobenzofuran-1-one

生成物 1

HCID 57753663(2-Fluoro-6-hydroxymethyl-4-trifluoromethyl-phenyl)-methanol

実験手順

Prepared in analogy to Example A16(a) from 4-Fluoro-6-trifluoromethyl-3H-isobenzofuran-1-one e and sodium borohydride. Colorless oil. MS (m/e): 225.1 ([M+H+, 100%).

出典と根拠

ORDレコード: ord-df8964264c0d4f8b917d453468251840
出典データセット: uspto-grants-2009_07
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US07557114B2

反応ノート

読み込み中…