N-bromobutanimide → Methyl 2-(4-bromomethylphenoxy)-2-(2-chlorophenyl)acetate

反応式

[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[CH:8]([O:13][C:14]1[CH:19]=[CH:18][C:17]([CH3:20])=[CH:16][CH:15]=1)[C:9]([O:11][CH3:12])=[O:10].C1C(=O)N([Br:28])C(=O)C1>>[Br:28][CH2:20][C:17]1[CH:18]=[CH:19][C:14]([O:13][CH:8]([C:3]2[CH:4]=[CH:5][CH:6]=[CH:7][C:2]=2[Cl:1])[C:9]([O:11][CH3:12])=[O:10])=[CH:15][CH:16]=1

参加物

反応物 2

HCID 67184N-bromobutanimide

HCID 19385716Methyl 2-(2-chlorophenyl)-2-(4-methylphenoxy)acetate

生成物 1

HCID 19385740Methyl 2-(4-bromomethylphenoxy)-2-(2-chlorophenyl)acetate収率 76.2%

実験手順

The product of Step B (0.200 g, 0.69 mmol) was brominated with NBS (117 mg, 0.66 mmol) and purified using the procedure described in Step C of Example 3, and afforded 0.186 g (73%) of the title compound.

後処理

custompurified

出典と根拠

ORDレコード: ord-cbe086446e3a4d1baa153ee8d3f1ed45
出典データセット: uspto-grants-1993_08
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US05240938

反応ノート

読み込み中…