Dimethylamine → Ethyl 2-cyano-3-(dimethylamino)acrylate
反応式
[CH3:1][NH:2][CH3:3].[C:4]([CH2:6][C:7]([O:9][CH2:10][CH3:11])=[O:8])#[N:5].[OH-].[Na+].[C:14]1(C)C=CC=CC=1>>[CH3:1][N:2]([CH:14]=[C:6]([C:4]#[N:5])[C:7]([O:9][CH2:10][CH3:11])=[O:8])[CH3:3]参加物
5
反応条件
- 温度
- 20 °C
実験手順
5.5 g of dimethylamine were condensed with 20.9 g of methoxymethyleneiminium methylsulphate at 0° C. After stirring for 1 hour at 20° C., excess dimethylamine and 70% of the resulting methanol were removed in vacuo. Analogously to Example 1, the salt obtained was reacted with 11.4 g of ethyl cyanoacetate and 4.0 g of NaOH in 140 ml of toluene. 93% of ethyl dimethylaminomethylenecyano-acetate were obtained, together with 1.2% of the corresponding methyl ester.
後処理
- customexcess dimethylamine and 70% of the resulting methanol were removed in vacuo
- customAnalogously to Example 1, the salt obtained
出典と根拠
- ORDレコード
- ord-ac039ce1701846b5b9325fee84f94c89
- 出典データセット
- uspto-grants-1993_08
- 特許番号
- US05241099
反応ノート
読み込み中…