1-Benzyloxycarbonyl-4-(3-pyridyl)-1,2,3,4-tetrahydropyridine → 3-(Piperidin-4-yl)pyridine
反応式
C(OC([N:11]1[CH:16]=[CH:15][CH:14]([C:17]2[CH:18]=[N:19][CH:20]=[CH:21][CH:22]=2)[CH2:13][CH2:12]1)=O)C1C=CC=CC=1.[H][H]>C(O)C.[Pd]>[N:19]1[CH:20]=[CH:21][CH:22]=[C:17]([CH:14]2[CH2:15][CH2:16][NH:11][CH2:12][CH2:13]2)[CH:18]=1参加物
5
実験手順
A solution of 1-benzyloxycarbonyl-4-(3-pyridyl)-1,2,3,4-tetrahydropyridine (0.714 in ethanol (50 mL) was treated with 10% palladium on carbon (0.1 g) and hydrogenated under a hydrogen atmosphere at room temperature and 3.44 bar for 16 hours. The reaction mixture was filtered through diatomaceous earth to remove the catalyst, and the resulting filtrate was evaporated to afford the piperidine (0.393 g); NMR (CDCl3): 1.7 (m, 4), 2.8 (m, 4), 3.2 (m, 2), 7.3 (m, 1), 7.5 (m, 1), 8.5 (m, 2); MS: m/z=162(M+1).
後処理
- filtrationThe reaction mixture was filtered through diatomaceous earth
- customto remove the catalyst
- customthe resulting filtrate was evaporated
出典と根拠
- ORDレコード
- ord-64a60d14893e4aad8b0b7d8105db3be9
- 出典データセット
- uspto-grants-1997_08
- 特許番号
- US05654299
反応ノート
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