4-(2-Benzyl-2,3-dihydro-1H-isoindol-5-yl)-tetrahydro-pyran-4-ol → 4-(2,3-Dihydro-1H-isoindol-5-yl)-tetrahydro-pyran-4-ol
反応式
C([N:8]1[CH2:16][C:15]2[C:10](=[CH:11][CH:12]=[C:13]([C:17]3([OH:23])[CH2:22][CH2:21][O:20][CH2:19][CH2:18]3)[CH:14]=2)[CH2:9]1)C1C=CC=CC=1>CO.[Pd]>[CH2:9]1[C:10]2[C:15](=[CH:14][C:13]([C:17]3([OH:23])[CH2:22][CH2:21][O:20][CH2:19][CH2:18]3)=[CH:12][CH:11]=2)[CH2:16][NH:8]1参加物
4
実験手順
To a stirred solution 0.39 mmol 4-(2-benzyl-2,3-dihydro-1H-isoindol-5-yl)-tetrahydro-pyran-4-ol in 20 ml methanol was added 40 mg 10% palladium on charcoal and the mixture was stirred under an atmosphere of hydrogen for 3 h. The reaction mixture was then filtered and the filtrate was concentrated in vacuo to yield the title compound as a yellow solid (100% yield). MS (m/e): 220.3 ([M+H]+, 100%).
後処理
- filtrationThe reaction mixture was then filtered
- concentrationthe filtrate was concentrated in vacuo
出典と根拠
- ORDレコード
- ord-339e995f353440878f69c6f08c4012cd
- 出典データセット
- uspto-grants-2009_07
- 特許番号
- US07557114B2
反応ノート
読み込み中…