4-(3-Isopropyl-4-methoxy-phenoxy)-3,5-dimethyl-nitrobenzene → 3,5-Dimethyl4-(3'-isopropyl-4'-methoxyphenoxy)-aniline

HRID 2256481ノート

反応式

HRID 2256481 の反応式
[CH3:1][C:2]1[CH:3]=[C:4]([N+:21]([O-])=O)[CH:5]=[C:6]([CH3:20])[C:7]=1[O:8][C:9]1[CH:14]=[CH:13][C:12]([O:15][CH3:16])=[C:11]([CH:17]([CH3:19])[CH3:18])[CH:10]=1>[Pt].C(O)C>[CH3:20][C:6]1[CH:5]=[C:4]([CH:3]=[C:2]([CH3:1])[C:7]=1[O:8][C:9]1[CH:14]=[CH:13][C:12]([O:15][CH3:16])=[C:11]([CH:17]([CH3:18])[CH3:19])[CH:10]=1)[NH2:21]

参加物

4

反応物 1

HCID 103136024-(3-Isopropyl-4-methoxy-phenoxy)-3,5-dimethyl-nitrobenzene

生成物 1

HCID 100167993,5-Dimethyl4-(3'-isopropyl-4'-methoxyphenoxy)-aniline

試薬・触媒・溶媒 2

HCID 23939Platinum触媒HCID 702Ethanol溶媒

実験手順

3,5-Dimethyl-4-(3'-isopropyl-4'-methoxyphenoxy)nitrobenzene (480 mg) and 50 mg of 10% platinum on carbon in 100 ml ethanol are reduced on a Parr shaker. Catalyst is removed by filtration through Celite and the filtrate stripped. The residue is taken up in ether and acidified with gaseous hydrogen chloride. The ether solution is chilled, filtered to remove insolubles, and stripped to afford 3,5-dimethyl-4-(3'-isopropyl-4'-methoxyphenoxy)-aniline hiedrochloride, m.p. 95°-100°.

後処理

  1. customCatalyst is removed by filtration through Celite
  2. temperatureThe ether solution is chilled
  3. filtrationfiltered
  4. customto remove insolubles

出典と根拠

ORDレコード
ord-7c2ab23343aa4745863b87cdacbbe6f9
出典データセット
uspto-grants-1997_08
特許番号
US05654468

反応ノート

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