Methanol → HCID 19027583、化合物

HRID 2256811ノート

反応式

HRID 2256811 の反応式
[C:1]1([C:7]2[N:11]=[C:10]([CH2:12][CH2:13][C:14](O)=[O:15])[O:9][N:8]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.CO>O1CCCC1>[C:1]1([C:7]2[N:11]=[C:10]([CH2:12][CH2:13][CH2:14][OH:15])[O:9][N:8]=2)[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1

参加物

4

反応物 2

HCID 887MethanolHCID 6659683-(3-phenyl-1,2,4-oxadiazol-5-yl)propanoic acid

生成物 1

HCID 19027583HCID 19027583、化合物収率 56.3%

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒2 回

実験手順

A solution of 2.5 ml of borane-methyl sulfide complex in 2M solution in tetrahydrofuran, 920 mg of 3-(3-phenyl-1,2,4-oxadiazol 5-yl)-propanoic acid (prepared by SRIRASTAVA et al., J. Heterocycl. Chem., Vol. 21, p. 1193 (1984) and 20 ml of tetrahydrofuran was stirred for one hour at ambient temperature. 10 ml of methanol were added over 5 minutes and evaporation to dryness under reduced pressure was carried out. The residue was chromatographed on silica (eluant: ethyl acetate - hexane (6-4)) to obtain 485 mg of the expected product.

後処理

  1. customevaporation to dryness under reduced pressure
  2. customThe residue was chromatographed on silica (eluant: ethyl acetate - hexane (6-4))

出典と根拠

ORDレコード
ord-d6a7c392a358417da35aeb7f62c06421
出典データセット
uspto-grants-1997_08
特許番号
US05656607

反応ノート

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