Hydrochloric Acid → 2-(4-n-Propylphenylthio)nonanoic acid

HRID 2257158

反応式

HRID 2257158 の反応式
[CH2:1]([C:4]1[CH:9]=[CH:8][C:7]([S:10][CH:11]([CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH3:23])[C:12]([O:14]CC)=[O:13])=[CH:6][CH:5]=1)[CH2:2][CH3:3].[OH-].[Na+].Cl>CO>[CH2:1]([C:4]1[CH:9]=[CH:8][C:7]([S:10][CH:11]([CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH3:23])[C:12]([OH:14])=[O:13])=[CH:6][CH:5]=1)[CH2:2][CH3:3]

参加物

5

反応物 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 14995384Ethyl 2-(4-n-Propylphenylthio)nonanoate

生成物 1

HCID 149953862-(4-n-Propylphenylthio)nonanoic acid収率 96%

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

A solution containing 5.7 (0.017 mole) of the title compound of Example 1, 35 ml of 1N aqueous sodium hydroxide solution (0.035 mole) and 3 ml methanol was refluxed overnight. The resulting solution was cooled to room temperature, acidified to pH 1.5 with 2N aqueous hydrochloric acid and extracted with 3×50 ml ethyl acetate. The combined ethyl acetate extracts were washed with 50 ml water and 50 ml saturated aqueous sodium chloride solution, dried over anhydrous sodium sulfate and concentrated in vacuo to yield the title compound as an oil (5.0 g, 96% yield) which was used in the subsequent reaction without further purification.

後処理

  1. temperaturewas refluxed overnight
  2. extractionextracted with 3×50 ml ethyl acetate
  3. washThe combined ethyl acetate extracts were washed with 50 ml water and 50 ml saturated aqueous sodium chloride solution
  4. dry with materialdried over anhydrous sodium sulfate
  5. concentrationconcentrated in vacuo

出典と根拠

ORDレコード
ord-e724042210d34632af98c871d08c3b04
出典データセット
uspto-grants-1997_08
特許番号
US05656634

関連ノート

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