(S)-5-(2-Hydroxyethyl)-2,2-dimethyl-1,3-dioxolan-4-one p-toluenesulfonate → (S)-5-Hexyl-2,2-dimethyl-1,3-dioxolan-4-one

温度

-10 °C

To a flame-dried 500 mL three-necked round bottom flask under nitrogen containing a suspension of 4.85 g (25.48 mmol) of cuprous iodide in 200 mL of anhydrous ether and held at -30° C. was added dropwise 31.85 mL of 1.6M n-BuLi (50.96 mmol) in hexanes. The dark red-brown solution was stirred at -30° C. to -40° C. for 2 hours and cooled to -78° C. (S)-5-(2-hydroxyethyl)-2,2-dimethyl-l,3-dioxolan-4-one p-toluenesulfonate (4.0 g, 12.74 mmol), dissolved in 30 mL of anhydrous ether and 10 mL of anhydrous tetrahydrofuran, was added dropwise while maintaining the temperature below -70° C. The reaction mixture was stirred for 18 hours at -78° C. Following completion (TLC monitoring), the reaction was warmed to -10° C. and quenched by the addition of 125 mL of precooled saturated ammonium chloride solution. Ether (100 mL) was added and the mixture filtered over Celite. The aqueous phase was extracted with 3×175 mL ether. The combined ether extract was washed with 2×125 mL of saturated ammonium chloride solution, 1×75 mL of water and 2×100 mL of brine, dried (Na2SO4), filtered and concentrated under reduced pressure. The product was purified (silica gel) using ethyl acetate:hexanes (1:5) as eluant to give 2.44 g (95%) of the title compound as a colorless oil: [α]D25 0.6°(c=1.9, CH3OH); IR (Kbr, cm-1) 2958, 2933, 2861, 1797; 1H NMR (CDCl3) δ 4.39 (dd, J=4.4, 7.1 Hz, 1H), 1.95-1.81 (m, 1H), 1.81-1.62 (m, 1H), 1.61 (s, 3H), 1.54 (s, 3H), 1.49-1.38 (m, 2H), 1.35-1.29 (m, 6H), 0.89 (t, J=6.6 13C NMR (CDCl3) δ 173.3, 110.2, 74.2, 31.7, 31.6, 28.8, 25.8, 24.8, 22.5, 13.9; HRMS calculated for C11H20O3 (M+), 200.1412, found 200.1422.

1. customheld at -30° C.
2. temperaturewhile maintaining the temperature below -70° C
3. stirringThe reaction mixture was stirred for 18 hours at -78° C
4. customquenched by the addition of 125 mL of precooled saturated ammonium chloride solution
5. additionEther (100 mL) was added
6. filtrationthe mixture filtered over Celite
7. extractionThe aqueous phase was extracted with 3×175 mL ether
8. extractionThe combined ether extract
9. washwas washed with 2×125 mL of saturated ammonium chloride solution, 1×75 mL of water and 2×100 mL of brine
10. dry with materialdried (Na2SO4)
11. filtrationfiltered
12. concentrationconcentrated under reduced pressure
13. customThe product was purified (silica gel)

ORDレコード

ord-229a75136a9f417d8b2a357f3768cf7f

出典データセット

uspto-grants-1997_08

DOI

10.6084/m9.figshare.5104873.v1

特許番号

US05656662