3-Bromo-1-propanol → 1-Pyrrolidinepropanol

HRID 225758

反応式

HRID 225758 の反応式
Br[CH2:2][CH2:3][CH2:4][OH:5].[NH:6]1[CH2:10][CH2:9][CH2:8][CH2:7]1>C1(C)C=CC=CC=1>[N:6]1([CH2:2][CH2:3][CH2:4][OH:5])[CH2:10][CH2:9][CH2:8][CH2:7]1

参加物

4

反応物 2

HCID 123083-Bromo-1-propanolHCID 31268Pyrrolidine

生成物 1

HCID 2093421-Pyrrolidinepropanol

試薬・触媒・溶媒 1

HCID 1140Toluene溶媒

実験手順

3-Bromopropan-1-ol (27.3 mL, 302 mmol) was added to a solution of pyrrolidine (47.2 g, 655 mmol) in toluene (1000 mL) and the mixture was stirred at room temperature for 48 hours. The reaction mixture was then filtered and the filtrate was evaporated under reduced pressure. The residue was distilled and the title product was obtained as a colourless liquid at 100° C./7 mmHg, (23.1 g, 59%).

後処理

  1. filtrationThe reaction mixture was then filtered
  2. customthe filtrate was evaporated under reduced pressure
  3. distillationThe residue was distilled

出典と根拠

ORDレコード
ord-2ac62587795a42abb14e610714f0697f
出典データセット
uspto-grants-2009_07
特許番号
US07557121B2

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