Hydroxide → 1-(2-Anilinoethyl)-4-methoxymethoxypiperidine

HRID 2257894ノート

反応式

HRID 2257894 の反応式
[NH:1]([C:8]([CH2:10][N:11]1[CH2:16][CH2:15][CH:14]([O:17][CH2:18][O:19][CH3:20])[CH2:13][CH2:12]1)=O)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[H-].[Al+3].[Li+].[H-].[H-].[H-].[OH-].O>O1CCCC1.C(OCC)(=O)C>[NH:1]([CH2:8][CH2:10][N:11]1[CH2:16][CH2:15][CH:14]([O:17][CH2:18][O:19][CH3:20])[CH2:13][CH2:12]1)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

参加物

7

反応物 4

HCID 961HydroxideHCID 962WaterHCID 21226445Aluminium lithium hydrideHCID 229236881-(Anilinocarbonylmethyl)-4-methoxymethoxypiperidine

生成物 1

HCID 229237061-(2-Anilinoethyl)-4-methoxymethoxypiperidine収率 98.6%

試薬・触媒・溶媒 2

HCID 8028Tetrahydrofuran溶媒2 回HCID 8857Ethyl Acetate溶媒

実験手順

A solution of 3.64 g of 1-(anilinocarbonylmethyl)-4-methoxymethoxypiperidine in 10 ml of tetrahydrofuran was added to a suspension of 630 mg of lithium aluminum hydride in 50 ml of tetrahydrofuran. The mixture was refluxed for 3 hours. To the reaction mixture were added 1.5 ml of an aqueous solution containing 10% of potassim hydroxide and 1.5 ml of water. The mixture was diluted with ethyl acetate, and the dilution was filtered. The solvent in the filtrate was removed by distillation to obtain 3.41 g of 1-(2-anilinoethyl)-4-methoxymethoxypiperidine.

後処理

  1. temperatureThe mixture was refluxed for 3 hours
  2. filtrationthe dilution was filtered
  3. customThe solvent in the filtrate was removed by distillation

出典と根拠

ORDレコード
ord-b943896e0875473197f6767596198555
出典データセット
uspto-grants-1997_08
特許番号
US05658926

反応ノート

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