Triethylamine → HCID 131720124、化合物
反応式
[NH2:1][CH:2]([CH:8]([C:18]1[CH:26]=[CH:25][C:21]2[O:22][CH2:23][O:24][C:20]=2[CH:19]=1)[C:9]1[CH:17]=[CH:16][C:12]2[O:13][CH2:14][O:15][C:11]=2[CH:10]=1)[C:3]([O:5][CH2:6][CH3:7])=[O:4].[C:27]1([CH:33]([C:37]2[CH:42]=[CH:41][CH:40]=[CH:39][CH:38]=2)[C:34](Cl)=[O:35])[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=1.C(N(CC)CC)C>C(Cl)(Cl)Cl>[O:22]1[C:21]2[CH:25]=[CH:26][C:18]([CH:8]([C:9]3[CH:17]=[CH:16][C:12]4[O:13][CH2:14][O:15][C:11]=4[CH:10]=3)[CH:2]([NH:1][C:34](=[O:35])[CH:33]([C:27]3[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=3)[C:37]3[CH:42]=[CH:41][CH:40]=[CH:39][CH:38]=3)[C:3]([O:5][CH2:6][CH3:7])=[O:4])=[CH:19][C:20]=2[O:24][CH2:23]1参加物
5
実験手順
The amino ester of Example 19 (0.510 g, 1.43 mmol) is mixed with diphenylacetyl chloride (0.346 g, 1.5 mmol) in 20 mL of dry chloroform. Triethylamine (0.6 mL, 4.3 mmol) is added to the reaction mixture and it is stirred for 2 hours. The solvent is evaporated and the residue is taken up into 75 mL of ethyl acetate. The solution is washed with 1N hydrochloric acid and saturated sodium bicarbonate respectively. The organic phase is dried (magnesium sulfate), filtered and purified by a short column to afford 0.552 g (70%) of product as a white solid;