反応式
F[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[O:8][Si:9]([C:12]([CH3:15])([CH3:14])[CH3:13])([CH3:11])[CH3:10].[F:16]C1C=CC=CC=1O.C([Li])(CC)C.[CH:29]([C:31]1[CH:43]=[CH:42][C:34]([C:35]([N:37]([CH2:40][CH3:41])[CH2:38][CH3:39])=[O:36])=[CH:33][CH:32]=1)=[O:30]>ClCCl.CO>[Si:9]([O:8][C:3]1[CH:4]=[CH:5][C:6]([F:16])=[C:7]([CH:2]=1)[CH:29]([C:31]1[CH:43]=[CH:42][C:34]([C:35]([N:37]([CH2:38][CH3:39])[CH2:40][CH3:41])=[O:36])=[CH:33][CH:32]=1)[OH:30])([C:12]([CH3:15])([CH3:14])[CH3:13])([CH3:11])[CH3:10]参加物
7
反応物 4
生成物 1
試薬・触媒・溶媒 2
実験手順
tert-Butyldimethylsilyl 2-fluorophenyl ether (2.73 g, 12 mmol), prepared from 2-fluorophenol by the method in Example 1, was treated with sec-butyllithium (11 mL of 1.1M solution in cyclohexane) and 4-formyl-N,N -diethylbenzamide, (2.46 g, 12 mmol) from Example 11, by the procedure described in Example 29. Chromatography on silica gel with 1% methanol in dichloromethane gave 1.77 g (34%) of 4-(5-(tert-butyidimethylsilyloxy)-2-fluoro-α-hydroxybenzyl)-N,N-diethylbenzamide as a yellow oil that crystallized on standing.
出典と根拠
- ORDレコード
- ord-ad0111c3fc5b49a9b471ef743a51984e
- 出典データセット
- uspto-grants-1997_08
- 特許番号
- US05658908
関連ノート
読み込み中…