Ibuprofen, (+-)- → Methyl 2-methylprop-2-enoate;2-methylprop-2-enoic acid
反応式
[C:1](O)(=O)C=C.[OH:6][C:7]([CH:9]([C:11]1C=CC(CC(C)C)=CC=1)[CH3:10])=[O:8]>>[C:7]([OH:8])(=[O:6])[C:9]([CH3:11])=[CH2:10].[CH3:1][O:6][C:7](=[O:8])[C:9]([CH3:11])=[CH2:10]参加物
3
実験手順
Acrylic acid, ibuprofen and poly(acrylic acid) (MW 2,000) and (MW 5,000) were purchased from Aldrich. Poly(methacrylic acid-methylmethacrylate) (Eudragit L) was provided by Rhom Pharma (Germany). Thionyl chloride, oxalyl chloride, and acetic anhydride were freshly distilled under nitrogen prior to use. All solvents were analytical grade.
出典と根拠
- ORDレコード
- ord-57aeddba888d4109b2b164a6f17e181b
- 出典データセット
- uspto-grants-1997_08
- 特許番号
- US05660851
反応ノート
読み込み中…