Water → Methyl 2-((4,6-Dimethoxypyrimidin-2-yl)oxy)-3-phenoxy-3-phenylbutanoate

HRID 2258459ノート

反応式

HRID 2258459 の反応式
[O:1]([C:8]([C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1)([CH3:15])[CH:9]([OH:14])[C:10]([O:12][CH3:13])=[O:11])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[H-].[Na+].[CH3:24][O:25][C:26]1[CH:31]=[C:30]([O:32][CH3:33])[N:29]=[C:28](S(C)(=O)=O)[N:27]=1.O>CN(C)C=O.C(O)(=O)C>[O:1]([C:8]([C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1)([CH3:15])[CH:9]([O:14][C:28]1[N:29]=[C:30]([O:32][CH3:33])[CH:31]=[C:26]([O:25][CH3:24])[N:27]=1)[C:10]([O:12][CH3:13])=[O:11])[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

参加物

7

反応物 4

HCID 962WaterHCID 24758Sodium hydrideHCID 8383634,6-Dimethoxy-2-(methylsulfonyl)pyrimidineHCID 15766824Methyl 3-phenoxy-3-phenyl-2-hydroxybutyrate2 回

生成物 1

HCID 15766825Methyl 2-((4,6-Dimethoxypyrimidin-2-yl)oxy)-3-phenoxy-3-phenylbutanoate

試薬・触媒・溶媒 2

HCID 176Acetic Acid溶媒HCID 6228Dimethylformamide溶媒

実験手順

4.4 g (15.4 mmol) of methyl 3-phenoxy-3-phenyl-2-hydroxybutyrate (compound 1.1) are dissolved in 40 ml of dimethylformamide, and 0.46 g (18.4 mmol) of sodium hydride are added. Stirring is carried out for 1 hour, after which 3.4 g (15.4 mmol) of 4,6-dimethoxy-2-methylsulfonylpyrimidine are added. After stirring has been carried out for 24 hours at room temperature, hydrolysis is effected carefully with 10 ml of water, the pH is brought to 5 with acetic acid and the solvent is distilled off under greatly reduced pressure. The residue is taken up in 100 ml of ethyl acetate, washed with water and dried over sodium sulfate and the solvent is distilled off. 10 ml of methyl tert-butyl ether are added to the residue and the precipitate formed is filtered off with suction. After drying, 1.6 g of a white powder remains.

後処理

  1. stirringAfter stirring
  2. waithas been carried out for 24 hours at room temperature
  3. customhydrolysis
  4. distillationthe solvent is distilled off under greatly reduced pressure
  5. washwashed with water
  6. dry with materialdried over sodium sulfate
  7. distillationthe solvent is distilled off
  8. addition10 ml of methyl tert-butyl ether are added to the residue
  9. customthe precipitate formed
  10. filtrationis filtered off with suction
  11. customAfter drying

出典と根拠

ORDレコード
ord-371f87754bd04e0c97a55b9b55aeaa5a
出典データセット
uspto-grants-1997_08
特許番号
US05661106

反応ノート

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