Methyl iodide → 3-Bromothioanisole

HRID 22592

反応式

HRID 22592 の反応式
[Br:1][C:2]1[CH:3]=[C:4]([SH:8])[CH:5]=[CH:6][CH:7]=1.[C:9](=O)([O-])[O-].[K+].[K+].IC>CC(C)=O>[CH3:9][S:8][C:4]1[CH:3]=[C:2]([Br:1])[CH:7]=[CH:6][CH:5]=1

参加物

5

反応物 3

HCID 6328Methyl iodideHCID 11430Potassium CarbonateHCID 80597m-Bromobenzenethiol

生成物 1

HCID 27356273-Bromothioanisole

試薬・触媒・溶媒 1

HCID 180Acetone溶媒

実験手順

To a solution of 3-bromothiophenol (10 g) in acetone (250 mL) was added potassium carbonate (14.6 g) and iodomethane (4.28 mL). The heterogenous mixture was refluxed for 4 hrs., cooled to room temperature, filtered, and concentrated under reduced pressure. Ether (200 mL) was added, and the mixture was filtered again and finally evaporated to dryness to yield the title compound.

後処理

  1. temperatureThe heterogenous mixture was refluxed for 4 hrs
  2. filtrationfiltered
  3. concentrationconcentrated under reduced pressure
  4. additionEther (200 mL) was added
  5. filtrationthe mixture was filtered again
  6. customfinally evaporated to dryness

出典と根拠

ORDレコード
ord-581984c1318441db9e89fd4f881319b7
出典データセット
uspto-grants-1995_06
特許番号
US05428171

関連ノート

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