8-Azaspiro(4.5)decane-7,9-dione → Buspirone

HRID 2259412

反応式

HRID 2259412 の反応式
[N:1]1[CH:6]=[CH:5][CH:4]=[N:3][C:2]=1[N:7]1[CH2:12][CH2:11][N:10]([CH2:13][C:14]#[C:15][CH2:16][N:17]2[C:26](=[O:27])[CH2:25][C:20]3([CH2:24][CH2:23][CH2:22][CH2:21]3)[CH2:19][C:18]2=[O:28])[CH2:9][CH2:8]1.[H][H].C1C2(CC(=O)NC(=O)C2)CCC1>S1C=CC=C1.[Pd]>[N:1]1[CH:6]=[CH:5][CH:4]=[N:3][C:2]=1[N:7]1[CH2:12][CH2:11][N:10]([CH2:13][CH2:14][CH2:15][CH2:16][N:17]2[C:26](=[O:27])[CH2:25][C:20]3([CH2:24][CH2:23][CH2:22][CH2:21]3)[CH2:19][C:18]2=[O:28])[CH2:9][CH2:8]1

参加物

6

反応物 3

HCID 1368438-Azaspiro(4.5)decane-7,9-dioneHCID 109050388-azaspiro[4,5]decane-8-{4-[4''-(2'''-pyrimidinyl)-1''-piperazinyl]-butyne/2/-yl}-7,9-dione /E/-2-butenedionate;8-azaspiro[4,5]decane-8-{4-[4''-(2'''-pyrimidinyl)-1''-piperazinyl]-butyne/2/-yl}-7,9-dione /E/-2-butenedionateHCID 178418361HCID 178418361、化合物2 回

生成物 1

HCID 2477Buspirone収率 100.1%

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 8030Thiophene溶媒2 回

実験手順

A solution of 100 g (0.26 mole) of 8-[4-[4-(pyrimidine-2-yl)-piperazine-1-yl]-but-2-inyl]-8-aza-spiro[4.5]decane-7,9-dione in 50 ml thiophen-free benzene is added to a suspension of 2 g of a palladium/carbon catalyst (palladium content about 5% by weight) and 50 ml of thiophen-free benzene under vigorous stirring at 20°-40° C. under the introduction of hydrogen under a pressure of 1 bar at such a rate that the hydrogen uptake of the unsaturated 8-[4-[4-pyrimidine-2-yl)-piperazine-1-yl]-but-2-inyl]-8-aza-spiro[4.5]decane-7,9-dione added is substantially identical with the calculated hydrogen consumption continuously measured with the aid of a gas burette. This practically means that when the addition of the active ingredient is stopped, the hydrogen consumption ceases within 5-10 seconds. The reaction temperature is 20°-40° C. and the reaction time is 1-4 hours. When the reduction has been terminated, the catalyst is filtered off. The catalyst can be directly used in the next hydrogenating operations without any further treatment. The filtrate is evaporated and the residue is suspended in isopropanol and filtered. Thus in the form of white crystals 100.3 g of 8-[4-[4-(pyrimidine-2yl)-piperazine-1-yl]-butyl]-8-aza-spiro[4.5]decane-7.9-dione base are obtained, yield: about 100%.Mp.:105°-106° C. (according to prior art 90°-98° C.). Content: (on the base) 99.8-100.1%. According to HPLC analysis the product contains only 0.1% of contaminations.

後処理

  1. additionadded
  2. customis substantially identical with the calculated hydrogen consumption
  3. additionthe addition of the active ingredient
  4. customthe hydrogen consumption
  5. customis 20°-40° C.
  6. waitthe reaction time is 1-4 hours
  7. customWhen the reduction has been terminated
  8. filtrationthe catalyst is filtered off
  9. customThe filtrate is evaporated
  10. filtrationfiltered

出典と根拠

ORDレコード
ord-7a45615a760f4f58ab44c9e9736f72b8
出典データセット
uspto-grants-1995_12
特許番号
US05473072

関連ノート

読み込み中…