HCID 19002930、化合物 → HCID 19002888、化合物
反応式
Cl[C:2]1[O:10][C:9]2[C:4](=[N:5][C:6]([CH3:11])=[CH:7][CH:8]=2)[C:3]=1[Cl:12].C([Li])(C)(C)C>C1COCC1>[Cl:12][C:3]1[C:4]2=[N:5][C:6]([CH3:11])=[CH:7][CH:8]=[C:9]2[O:10][CH:2]=1参加物
4
実験手順
To a solution of 2,3-dichloro-5-methylfuro[3,2-b]pyridine (0.661 g, 3.27 mmol) (Example 12, Step 2) in 16 mL of THF was added a 1.7M solution of t-butyllithium (4.04 mL, 6.87 mmol). After 30 min the solution was quenched at -78° C. with methanol and a solution of NH4C1. The reaction was brought to room temperature and extracted with EtOAc. The organic solvents were evaporated and the title compound was purified by flash chromatography on silica with EtOAc:hexane 1:4 to yield 0.444 g (81%).
後処理
- customAfter 30 min the solution was quenched at -78° C. with methanol
- customwas brought to room temperature
- extractionextracted with EtOAc
- customThe organic solvents were evaporated
- customthe title compound was purified by flash chromatography on silica with EtOAc:hexane 1:4
- customto yield 0.444 g (81%)
出典と根拠
- ORDレコード
- ord-06347123ff744e688129a25fe29d93b1
- 出典データセット
- uspto-grants-1995_12
- 特許番号
- US05472964
反応ノート
読み込み中…