Methyl o-toluate → Methyl 2-(bromomethyl)benzoate
反応式
[CH3:1][C:2]1[CH:11]=[CH:10][CH:9]=[CH:8][C:3]=1[C:4]([O:6][CH3:7])=[O:5].[Br:12]N1C(=O)CCC1=O>C(Cl)(Cl)(Cl)Cl.C(OOC(=O)C1C=CC=CC=1)(=O)C1C=CC=CC=1>[Br:12][CH2:1][C:2]1[CH:11]=[CH:10][CH:9]=[CH:8][C:3]=1[C:4]([O:6][CH3:7])=[O:5]参加物
5
実験手順
To a mixture of methyl 2-methylbenzoate (5.0 g, 0.033 mmol) and N-bromosuccinimide (5.9 g, 0.033 mmol) in CCl4 (50 mL) was added benzoyl peroxide (0.04 g, 0.00016 mmol). The mixture was heated to reflux for 1.5 h, cooled to room temperature, filtered through Celite, and concentrated to afford methyl 2-(bromomethyl)benzoate (7.2 g, ca. 94% mass recovery), which was contaminated with ca. 14% unreacted starting material and was used without purification.
後処理
- temperatureThe mixture was heated
- temperatureto reflux for 1.5 h
- filtrationfiltered through Celite
- concentrationconcentrated
出典と根拠
- ORDレコード
- ord-cf3f803730124b61b67889dd940bee60
- 出典データセット
- uspto-grants-2009_07
- 特許番号
- US07557135B2
反応ノート
読み込み中…