4-Bromo-2-nitroanisole → cis-3,5-Dimethyl-1-[4-(methyloxy)-3-nitrophenyl]piperazine
反応式
COc1ccc(Br)cc1[N+](=O)[O-].C[C@@H]1CNC[C@H](C)N1>C1COCCO1.CC(=O)O.CC(=O)O.O=C([O-])[O-].[Cs+].[Cs+].[Pd].c1ccc(P(c2ccccc2)c2ccc3ccccc3c2-c2c(P(c3ccccc3)c3ccccc3)ccc3ccccc23)cc1>COc1ccc(N2C[C@@H](C)N[C@@H](C)C2)cc1[N+](=O)[O-]参加物
反応条件
- 温度
- 100 °C
実験手順
To a solution of 4-bromo-1-methoxy-2-nitrobenzene (1500 mg, 6.46 mmol) in dioxane (40 mL) was added (2R,6S)-2,6-dimethylpiperazine (2215 mg, 19.39 mmol) followed by cesium carbonate (3159 mg, 9.70 mmol), 2,2'-bis(diphenylphosphino)-1,1'-binaphthyl (564 mg, 0.91 mmol) and diacetoxypalladium (145 mg, 0.65 mmol). The resulting mixture was heated at 100 °C under argon over night (black). LCMS Ok. The solids were filtered through celite and washed with ethyl acetate. The ethyl acetate was evaporated under reduced pressure and the crude product was purified by flash- chromatograpy eluated with Dichloromethane/ 2 M NH3 in Methanol 100/0 =>80/20 over 20 min. The pure fractions was collected and concentrated to give (3R,5S)-1-(4-methoxy-3-nitrophenyl)-3,5-dimethylpiperazine (1540 mg, 90 %) as red solid.
出典と根拠
- ORDレコード
- ord-5dbc6ee86ad94d33b87d1fb77112c522
- 出典データセット
- 750 AstraZeneca ELN dataset
- 元リンク
- 出典を表示
反応ノート
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