Acetyl chloride → N-(2,3-dihydroxypropyl)-N-(hexadecyl)ethanamide

HRID 2260079

反応式

HRID 2260079 の反応式
[C:1](Cl)(=[O:3])[CH3:2].[OH:5][CH:6]([CH2:25][OH:26])[CH2:7][NH:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH3:24]>C(Cl)(Cl)Cl>[OH:5][CH:6]([CH2:25][OH:26])[CH2:7][N:8]([CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH3:24])[C:1](=[O:3])[CH3:2]

参加物

4

反応物 2

HCID 6367Acetyl chlorideHCID 1110073-(Hexadecylamino)propane-1,2-diol

生成物 1

HCID 18999304N-(2,3-dihydroxypropyl)-N-(hexadecyl)ethanamide収率 26%

試薬・触媒・溶媒 1

HCID 6212Chloroform溶媒

実験手順

Acetyl chloride (1.15g. 14.8 mmoles) was added dropwise to a reactor containing N-(2,3-dihydroxypropyl)-hexadecylamine (1.5 g, 4.3 mmoles) in 3 mL of chloroform. The reaction was stirred for 16 hours at room temperature. When the reaction was completed, the, mixture was concentrated, ethanol and water was added, and the pH of the reaction was adjusted to 14. This mixture was extracted with chloroform, and organic layer was collected and concentrated. The sample was purified on a silica column chromatography to give 0.4 g of product.

後処理

  1. concentrationthe, mixture was concentrated
  2. additionethanol and water was added
  3. extractionThis mixture was extracted with chloroform, and organic layer
  4. customwas collected
  5. concentrationconcentrated
  6. customThe sample was purified on a silica column chromatography

出典と根拠

ORDレコード
ord-8281afeacc564c11883c03f614970d5d
出典データセット
uspto-grants-1995_12
特許番号
US05476661

関連ノート

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