Hexanoyl chloride → HCID 18999305、化合物

HRID 2260080

反応式

HRID 2260080 の反応式
[C:1](Cl)(=[O:7])[CH2:2][CH2:3][CH2:4][CH2:5][CH3:6].[OH:9][CH:10]([CH2:29][OH:30])[CH2:11][NH:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][CH2:26][CH2:27][CH3:28]>C(Cl)(Cl)Cl>[OH:9][CH:10]([CH2:29][OH:30])[CH2:11][N:12]([CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][CH2:26][CH2:27][CH3:28])[C:1](=[O:7])[CH2:2][CH2:3][CH2:4][CH2:5][CH3:6]

参加物

4

反応物 2

HCID 67340Hexanoyl chlorideHCID 1110073-(Hexadecylamino)propane-1,2-diol

生成物 1

HCID 18999305HCID 18999305、化合物収率 19.1%

試薬・触媒・溶媒 1

HCID 6212Chloroform溶媒

実験手順

Hexanoyl chloride (2.65g, 19.7 mmoles) was added dropwise to a reactor containing N-(2,3-dihydroxypropyl)-hexadecylamine (2.65g, 19.7 mmoles)in 8 mL of chloroform. The reaction was stirred for 16 hours at room temperature. When the reaction was completed, the mixture was concentrated, ethanol and water was added, and the pH of the reaction was adjusted to 14. This mixture was extracted with chloroform, and organic layer was collected and concentrated. The crude sample was purified on silica column chromatography to give 1.56 g of product.

後処理

  1. concentrationthe mixture was concentrated
  2. additionethanol and water was added
  3. extractionThis mixture was extracted with chloroform, and organic layer
  4. customwas collected
  5. concentrationconcentrated
  6. customThe crude sample was purified on silica column chromatography

出典と根拠

ORDレコード
ord-889bd1ab51a340bc9c1000bbfc525480
出典データセット
uspto-grants-1995_12
特許番号
US05476661

関連ノート

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