1-(Chloromethyl)-2-fluoro-3,4-dimethoxybenzene → 2-Fluoro-3,4-dimethoxybenzyl acetate

HRID 2260258ノート

反応式

HRID 2260258 の反応式
Cl[CH2:2][C:3]1[CH:8]=[CH:7][C:6]([O:9][CH3:10])=[C:5]([O:11][CH3:12])[C:4]=1[F:13].[C:14]([O-:17])(=[O:16])[CH3:15].[K+]>CN(C)C=O>[C:14]([O:17][CH2:2][C:3]1[CH:8]=[CH:7][C:6]([O:9][CH3:10])=[C:5]([O:11][CH3:12])[C:4]=1[F:13])(=[O:16])[CH3:15]

参加物

4

反応物 2

HCID 2374111-(Chloromethyl)-2-fluoro-3,4-dimethoxybenzeneHCID 517044Potassium Acetate

生成物 1

HCID 536894592-Fluoro-3,4-dimethoxybenzyl acetate

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

実験手順

5.5 g of α-chloro-2-fluoro-3,4-dimethoxytoluene and 4.05 g of potassium acetate are stirred at 80° for 25 hours in 50 ml of dimethylformamide. The reaction mixture is subsequently poured into 150 ml of ice-water and extracted with ether. The ether phases are washed with sodium chloride solution, dried over sodium sulfate and evaporated. 2-fluoro-3,4-dimethoxybenzyl acetate is obtained as an oil.

後処理

  1. extractionextracted with ether
  2. washThe ether phases are washed with sodium chloride solution
  3. dry with materialdried over sodium sulfate
  4. customevaporated

出典と根拠

ORDレコード
ord-b43d35b7857945c88cf3c491bb8ad2fe
出典データセット
uspto-grants-1995_12
特許番号
US05476875

反応ノート

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