Sodium Carbonate → 1-(2'-Hexyldecyl)-2-ethyl-4,5,6,7-tetrahydrobenzimidazole

HRID 2260470ノート

反応式

HRID 2260470 の反応式
[CH2:1]([C:3]1[NH:4][C:5]2[CH2:11][CH2:10][CH2:9][CH2:8][C:6]=2[N:7]=1)[CH3:2].Br[CH2:13][CH:14]([CH2:23][CH2:24][CH2:25][CH2:26][CH2:27][CH3:28])[CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH3:22].C(=O)([O-])[O-].[Na+].[Na+]>COCCO>[CH2:23]([CH:14]([CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH3:22])[CH2:13][N:7]1[C:6]2[CH2:8][CH2:9][CH2:10][CH2:11][C:5]=2[N:4]=[C:3]1[CH2:1][CH3:2])[CH2:24][CH2:25][CH2:26][CH2:27][CH3:28]

参加物

5

反応物 3

HCID 10340Sodium CarbonateHCID 18459580Pentadecane, 7-(bromomethyl)-HCID 189979322-Ethyl-4,5,6,7-tetrahydrobenzimidazole

生成物 1

HCID 189979291-(2'-Hexyldecyl)-2-ethyl-4,5,6,7-tetrahydrobenzimidazole

試薬・触媒・溶媒 1

HCID 80192-Methoxyethanol溶媒

実験手順

2-Ethyl-4,5,6,7-tetrahydrobenzimidazole (14.3 parts), 2-methoxyethanol (30 parts), 1-bromo-2-hexyldecane (35 parts) and sodium carbonate (5.7 parts) are stirred together and heated at 125°-135° C. below a reflux condenser for 15 hours. The reaction mixture is cooled and extracted with a mixture of toluene (150 parts) and ethyl acetate (50 parts) and the extract is washed successively with water, dilute sulphuric acid, dilute sodium hydroxide, and water, and then distilled yielding 1-(2'-hexyldecyl)-2-ethyl-4,5,6,7-tetrahydrobenzimidazole (V) (16.6 parts), b.p. 185°-200° at 0.2 mm pressure.

後処理

  1. temperatureheated at 125°-135° C. below a reflux condenser for 15 hours
  2. temperatureThe reaction mixture is cooled
  3. extractionextracted with a mixture of toluene (150 parts) and ethyl acetate (50 parts)
  4. washthe extract is washed successively with water, dilute sulphuric acid, dilute sodium hydroxide, and water
  5. distillationdistilled

出典と根拠

ORDレコード
ord-545b4c0de776409085a77ad9539a0544
出典データセット
uspto-grants-1995_12
特許番号
US05478539

反応ノート

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