Acetyl chloride → N-(2-phenylpropan-2-yl)acetamide

HRID 2260565ノート

反応式

HRID 2260565 の反応式
[C:1](Cl)(=[O:3])[CH3:2].[C:5]([NH2:14])([C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1)([CH3:7])[CH3:6].[OH-].[Na+].C(=O)([O-])[O-].[K+].[K+]>C1(C)C=CC=CC=1>[CH3:6][C:5]([NH:14][C:1](=[O:3])[CH3:2])([C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1)[CH3:7]

参加物

6

反応物 4

HCID 6367Acetyl chlorideHCID 11430Potassium CarbonateHCID 14798Sodium HydroxideHCID 68509Cumylamine

生成物 1

HCID 10749810N-(2-phenylpropan-2-yl)acetamide収率 86.7%

試薬・触媒・溶媒 1

HCID 1140Toluene溶媒

実験手順

Acetyl chloride (62 g) was dropwise added to a solution (1 l) of cumylamine (90 g) and a 48% aqueous solution of sodium hydroxide (70 ml) in toluene under ice-cooling and the mixture was stirred at room temperature for 5 hours. After completion of the reaction, the mixture was neutralized with a saturated aqueous solution of potassium carbonate and extracted with ethyl acetate. The extract was washed with water and dried. The solvent was distilled away under reduced pressure to give 102.3 g of N-(1-methyl-1-phenylethyl)acetamide.

後処理

  1. customAfter completion of the reaction
  2. extractionextracted with ethyl acetate
  3. washThe extract was washed with water
  4. customdried
  5. distillationThe solvent was distilled away under reduced pressure

出典と根拠

ORDレコード
ord-d3ceca01eb3a4569a2100843ff68ce52
出典データセット
uspto-grants-1995_12
特許番号
US05478838

反応ノート

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