Ethyl benzoate → N-(2-hydroxyethyl)-N-methylbenzamide

Ethyl benzoate (16.0 g, 15.3 ml) was dissolved in 2-(N-methylamino)ethanol (200 ml) and the mixture heated at reflux for 17.5 hours, cooled and diluted with water (1 l). The mixture was extracted with dichloromethane (4×200 ml), and the combined dichloromethane solutions washed with brine (300 ml), dried (MgSO4) and evaporated. The title compound, an oil, was used without further purification.

1. temperaturethe mixture heated
2. temperatureat reflux for 17.5 hours
3. temperaturecooled
4. extractionThe mixture was extracted with dichloromethane (4×200 ml)
5. washthe combined dichloromethane solutions washed with brine (300 ml)
6. dry with materialdried (MgSO4)
7. customevaporated
8. customThe title compound, an oil, was used without further purification

ORDレコード

ord-b1e3069bf01a4dadac9d2d81c0cd3018

出典データセット

uspto-grants-1995_12

DOI

10.6084/m9.figshare.5104873.v1

特許番号

US05478851