Sodium Hydroxide → 3-[3-(Methylphenylsulfamoyl)phenyl]acrylic acid

HRID 226124ノート

反応式

HRID 226124 の反応式
C[O:2][C:3](=[O:23])[CH:4]=[CH:5][C:6]1[CH:11]=[CH:10][CH:9]=[C:8]([S:12](=[O:22])(=[O:21])[N:13]([CH3:20])[C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=2)[CH:7]=1.[OH-].[Na+]>CO>[CH3:20][N:13]([C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1)[S:12]([C:8]1[CH:7]=[C:6]([CH:5]=[CH:4][C:3]([OH:23])=[O:2])[CH:11]=[CH:10][CH:9]=1)(=[O:21])=[O:22]

参加物

4

反応物 2

HCID 14798Sodium HydroxideHCID 670195883-[3-(Methylphenylsulfamoyl)phenyl]acrylic acid methyl ester

生成物 1

HCID 670195313-[3-(Methylphenylsulfamoyl)phenyl]acrylic acid収率 94.5%

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

3-[3-(Methylphenylsulfamoyl)phenyl]acrylic acid methyl ester (4b) (0.150 g, 0.45 mmol) was suspended in methanol (2 ml), 1 N NaOH solution (1.35 ml, 1.35 mmol) was added and the resultant solution was stirred at ambient temperature overnight. The reaction mixture was partitioned between ethyl acetate and water. The aqueous layer was acidified with 10% HCl and extracted with ethyl acetate. The organic layer was washed successively with water, saturated NaCl, and dried (Na2SO4). The solvent was removed to give the title compound (0.135 g, 94%).

後処理

  1. customThe reaction mixture was partitioned between ethyl acetate and water
  2. extractionextracted with ethyl acetate
  3. washThe organic layer was washed successively with water, saturated NaCl
  4. dry with materialdried (Na2SO4)
  5. customThe solvent was removed

出典と根拠

ORDレコード
ord-b79d696ecdf648d69028bd8b058d6e62
出典データセット
uspto-grants-2009_07
特許番号
US07557140B2

反応ノート

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