1-Indanone → 2-(4-Hexyloxy-benzylidene)-indan-1-one

HRID 22613

反応式

HRID 22613 の反応式
[C:1]1(=[O:10])[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[CH2:3][CH2:2]1.[OH-].[Na+].[CH2:13]([O:19][C:20]1[CH:27]=[CH:26][C:23]([CH:24]=O)=[CH:22][CH:21]=1)[CH2:14][CH2:15][CH2:16][CH2:17][CH3:18]>C(O)C.O>[CH2:13]([O:19][C:20]1[CH:27]=[CH:26][C:23]([CH:24]=[C:2]2[CH2:3][C:4]3[C:9](=[CH:8][CH:7]=[CH:6][CH:5]=3)[C:1]2=[O:10])=[CH:22][CH:21]=1)[CH2:14][CH2:15][CH2:16][CH2:17][CH3:18]

参加物

6

反応物 3

HCID 67351-IndanoneHCID 14798Sodium HydroxideHCID 79816p-(Hexyloxy)benzaldehyde

生成物 1

HCID 688648672-(4-Hexyloxy-benzylidene)-indan-1-one

試薬・触媒・溶媒 2

HCID 702Ethanol溶媒3 回HCID 962Water溶媒

実験手順

1-Indanone (4.17 g, 0.032 mol) was dissolved in ethanol (20 ml), and was added to sodium hydroxide (0.44 g, 0.011 mol) dissolved in water (8 ml) and ethanol (3 ml) and was left to stir for 20 min. 4-(Hexyloxy)benzaldehyde (6.4 ml, 0.031 mol), dissolved in ethanol (35 ml), was added to the mixture and was stirred for 4 hours. The product was isolated by vacuum filtration and was washed with cold ethanol (2×20 ml) and was dried in a vacuum oven. Yield=8.47 g, 85%. 1H NMR and 13C NMR gave expected signals.

後処理

  1. additionwas added to the mixture
  2. stirringwas stirred for 4 hours
  3. customThe product was isolated by vacuum filtration
  4. washwas washed with cold ethanol (2×20 ml)
  5. customwas dried in a vacuum oven
  6. custom1H NMR and 13C NMR gave expected signals

出典と根拠

ORDレコード
ord-0a076eed5552481f957a6c3c15c7d65e
出典データセット
uspto-grants-2005_02
特許番号
US06849203B2

関連ノート

読み込み中…