Water → HCID 57736326、化合物
反応式
[CH3:1][C:2]([C:8]1[O:12][N:11]=[C:10]([C:13](OCC)=[O:14])[CH:9]=1)([O:4][CH2:5][C:6]#[CH:7])[CH3:3].[BH4-].[Na+].O>C(O)C>[CH3:3][C:2]([C:8]1[O:12][N:11]=[C:10]([CH2:13][OH:14])[CH:9]=1)([O:4][CH2:5][C:6]#[CH:7])[CH3:1]参加物
5
実験手順
0.25 g of ethyl 5-[1-methyl-1-(2-propynyloxy)ethyl]isoxazole-3-carboxylate was dissolved in 2 ml of ethanol, and 0.1 g of sodium borohydride was then added. The mixture was stirred at room temperature for 5 hours. After 20 ml of water was added, the reaction mixture was extracted with ethyl acetate. The organic layer was dried over anhydrous magnesium sulfate, filtered and then concentrated under reduced pressure. The residue was subjected to silica gel column chromatography to obtain 0.20 g of {5-[1-methyl-1-(2-propynyloxy)ethyl]isoxazol-3-yl}methanol.
後処理
- extractionthe reaction mixture was extracted with ethyl acetate
- dry with materialThe organic layer was dried over anhydrous magnesium sulfate
- filtrationfiltered
- concentrationconcentrated under reduced pressure
出典と根拠
- ORDレコード
- ord-853e9efc2803403d964bec3a6ee8f796
- 出典データセット
- uspto-grants-2010_12
- 特許番号
- US07846956B2
反応ノート
読み込み中…