Thionyl Chloride → 5-(Chloromethyl)-3-methoxy-1,2-oxazole

HRID 2261363ノート

反応式

HRID 2261363 の反応式
[CH3:1][O:2][C:3]1[CH:7]=[C:6]([CH2:8]O)[O:5][N:4]=1.S(Cl)([Cl:12])=O>ClCCl>[Cl:12][CH2:8][C:6]1[O:5][N:4]=[C:3]([O:2][CH3:1])[CH:7]=1

参加物

4

反応物 2

HCID 24386Thionyl ChlorideHCID 106782583-Methoxy-5-isoxazolemethanol

生成物 1

HCID 100805435-(Chloromethyl)-3-methoxy-1,2-oxazole

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

1.55 g of (3-methoxyisoxazol-5-yl)methanol was dissolved in 30 ml of dichloromethane, and 2 ml of thionyl chloride was then added. The mixture was stirred at room temperature for 1 hour. The reaction mixture was concentrated under reduced pressure to obtain 1.30 g of 5-(chloromethyl)-3-methoxyisoxazole.

後処理

  1. concentrationThe reaction mixture was concentrated under reduced pressure

出典と根拠

ORDレコード
ord-34a66417c5ec4ca4a731d514b97630a2
出典データセット
uspto-grants-2010_12
特許番号
US07846956B2

反応ノート

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